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TOC Analysis & Water Quality

TOC Analysis & Water Quality

TOC analyzers are widely used in the pharmaceutical industry, water industry, in laboratories and research groups throughout the world. Beckman Coulter Anatel PAT700 TOC analyzers are specifically designed to help demonstrate compliance to the latest pharmacopoeia requirements for TOC and conductivity for purified water and water for injection.


  • TOC, uncompensated conductivity and temperature in just one analyzer – Fully calibrated and validated to USP 643 & USP 645
  • Low cost of ownership – 12 month service and calibration intervals
  • Root-cause analysis support – water sample automatically taken if there is a TOC excursion
  • All SOPs are pre-loaded into the PAT700, leading users step-by step with on-screen pictures and prompts

Anatel PAT 700 Advantages

Low Cost of Ownership

  • 12 month service intervals supported by auto-switching Main and Standby UV oxidation lamps with UV output monitoring
  • No chemicals/reagents required – PAT700 just uses strong UV lamps to oxidize TOC
  • No peristaltic pump tubing or pump heads to replace – PAT700 uses water system pressure to push sample into measurement cell for analysis

Improved Compliance

  • The PAT700 can be fully calibrated and validated for compliance to USP 643 for TOC and USP 645 for conductivity
  • Complete oxidation to EP 2.2.44 requirements – the PAT700 ensures complete TOC oxidation through oxidation dynamic end-point detection
  • 21CFR part 11 support – everyday users can view TOC and Conductivity results as a Guest without the ability to make any changes to the PAT700. Initial configuration and subsequent changes are protected through multi-level user name and password protection
  • Dual-stream version available to demonstrate compliance both at the start and end of water loops simultaneously

Root Cause Analysis Support

  • User can pre-program the PAT700 so that at a pre-determined TOC level, it will capture a water sample which can then be later analyzed in the QC Lab to assist root cause analysis should a TOC excursion be detected
  • On-board grab sampler allows the user to take samples from different locations/use points to support root cause analysis

Reduced Training Burden

  • All SOPs are pre-loaded into the PAT700, leading users step-by step with on-screen pictures and prompts
  • All Calibration and System Suitability standards come with certified value data and use by dates programmed into an RFID tag on the bottle itself. Following the on-screen SOPs the user is prompted to load the bottles and the PAT700 then reads the RFID tags on the bottles. If the bottles have been loaded in the wrong order, or if they have expired the PAT700 provides a warning on the touch-screen. The PAT700 then uploads certified values, carries out the test and automatically calculates a pass/fail result and provides a report.
Real-time Total Organic Carbon (TOC) monitoring provides numerous benefits across various industries, particularly in applications related to water quality, environmental monitoring, pharmaceutical manufacturing, and more. Here are some of the key advantages:
Immediate Detection of Contaminants

Real-time TOC monitoring allows for the rapid detection of organic contaminants in water or other fluids. This enables quick response and corrective actions to prevent product or process contamination.

Process Control

Industries like pharmaceuticals and semiconductor manufacturing rely on precise control of organic impurities. Real-time TOC monitoring using TOC analyzers helps maintain consistent quality and compliance with regulatory standards by adjusting processes in real time.

Reduced Downtime

By continuously monitoring TOC levels, companies can identify issues early, reducing the risk of unexpected shutdowns and minimizing production downtime.

Cost Savings

Detecting contamination or deviations in TOC levels in real time using TOC analyzers can prevent the need for costly product recalls, rework, or equipment cleaning.

Environmental Compliance

Industries dealing with wastewater discharge are often subject to strict environmental regulations. Real-time TOC monitoring ensures compliance and helps avoid fines and penalties for exceeding discharge limits.

Data Logging and Reporting

Real-time TOC monitoring systems typically include data logging and reporting capabilities. This data can be useful for historical analysis, auditing, and compliance documentation.

Efficient Resource Utilization

By continuously monitoring TOC, industries can optimize the use of water, chemicals, and energy resources, reducing waste and operational costs.

Quality Assurance

In industries like food and beverage production, real-time TOC monitoring ensures the quality and safety of products by detecting organic contaminants that could compromise consumer health.

Process Optimization

Real-time TOC data from TOC analyzers can be used to fine-tune processes, leading to improved efficiency and reduced resource consumption.

Early Warning for Equipment Failures

Abnormal TOC levels can indicate equipment malfunction or deterioration. Real-time monitoring can provide early warning, allowing for preventive maintenance and avoiding costly breakdowns.

Validation of Cleaning Procedures

In industries where cleanliness is critical, such as pharmaceuticals and biotechnology, real-time TOC monitoring verifies the effectiveness of cleaning processes, ensuring that equipment is properly sanitized.


Using TOC analyzers and real-time TOC monitoring contributes to a safer working environment by identifying potential hazards associated with organic contamination.

Research and Development

Real-time TOC monitoring can aid in research and development efforts by providing continuous data on the impact of process changes and the behavior of organic compounds.

Complimentary Products

Alpha Scientific also offers a wide range of complimentary products for cleanroom and facility monitoring, HEPA filter testing, particle counting and many other applications.